2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Aldehyde Dehydrogenase (ALDH)

Aldehyde Dehydrogenase (ALDH)

Aldehyde Dehydrogenase (ALDH)

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Aldehyde Dehydrogenases (ALDHs) are a superfamily of NADP+-dependent enzymes that metabolize endogenous and exogenous aldehydes to corresponding carboxylic acids. This superfamily of proteins is comprised of 19 isozymes, with constitutive activity of at least one isozyme observed in a majority of mammalian tissues. The ALDHs play important roles, among other things, in cellular detoxification, the protection against ultraviolet radiation-induced damage, and amino acid metabolism.

The ALDH1A subfamily plays a pivotal role in embryogenesis and development by mediating retinoic acid signaling. ALDH2, as a key enzyme that oxidizes acetaldehyde, is crucial for alcohol metabolism. ALDH1A1 and ALDH3A1 are lens and corneal crystallins, which are essential elements of the cellular defense mechanism against ultraviolet radiation-induced damage in ocular tissues. Many ALDH isozymes are important in oxidizing reactive aldehydes derived from lipid peroxidation and thereby help maintain cellular homeostasis. Increased expression and activity of ALDH isozymes have been reported in various human cancers and are associated with cancer relapse. As a direct consequence of their significant physiological and toxicological roles, inhibitors of the ALDH enzymes have been developed to treat human diseases.

Aldehyde Dehydrogenase (ALDH) Isoform Specific Products:

Aldehyde Dehydrogenase (ALDH) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-159111
    KS124
    		Inhibitor
    KS124 (compound 3) is a potent ALDH inhibitor. KS124 shows inhibition for ALDH1A1, ALDH1A3, ALDH3A1. KS124 shows antiproliferative activity. KS124 induces apoptosis and ROS production.
    KS124
  • HY-178943
    Neuroprotective agent 15
    		Inhibitor
    Neuroprotective agent 15 (Compound 3e) is a neuroprotective agent. Neuroprotective agent 15 is a selective butyrylcholinesterase (BChE) inhibitor, with IC50 values of 2.6 and 114.3 μM for BChE and AChE respectively. Neuroprotective agent 15 has cannabinoid CB2 receptor (CB2 receptor) agonistic activity. Neuroprotective agent 15 can reduce cell death, LDH release and Caspase-3/7 activity, and inhibit apoptosis. Neuroprotective agent 15 can reduce the formation of superoxide free radicals, maintain cell morphology, and significantly lower oxidative stress levels. Neuroprotective agent 15 can be used in the research of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.
    Neuroprotective agent 15
  • HY-177639A
    Lefelsiran sodium
    		Inhibitor
    Lefelsiran sodium is a siRNA targeted to ALDH2. It is used for the study of alcohol use disorder.
    Lefelsiran sodium
  • HY-183767
    Aurora kinase/ALK-IN-1
    		Inhibitor
    Aurora kinase/ALK-IN-1 is a dual Aurora A kinase and ALK inhibitor with IC50 values of 0.296 μM and 0.332 μM, respectively. Aurora kinase/ALK-IN-1 induces G2/M cell cycle arrest, triggers mitochondrial apoptosis, elevates intracellular reactive oxygen species (ROS) levels, and inhibits ALDH1 activity. Aurora kinase/ALK-IN-1 demonstrates cytotoxicity and tumor selectivity. Aurora kinase/ALK-IN-1 can be used for the research of anaplastic large cell lymphoma.
    Aurora kinase/ALK-IN-1
  • HY-157872
    ALDH1A1-IN-4
    		Inhibitor
    ALDH1A1-IN-4 (compound A1) is a potent inhibitor of aldehyde dehydrogenase (ALDH) A1, with IC50 value of 0.32 μM. ALDH1A1-IN-4 plays an important role in cancer research.
    ALDH1A1-IN-4
  • HY-158026
    ALDH1A1-IN-5
    		Inhibitor
    ALDH1A1-IN-5 (compound 25) is a potent aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor with EC50 value of 83, 45, 43 µM for ALDH1A1, ALDH1A2, ALDH1A3, respectively. ALDH1A1-IN-5 has the potential for the research of high-grade serous ovarian cancer (HGSOC).
    ALDH1A1-IN-5
  • HY-76006R
    3-Hydroxybenzaldehyde (Standard)
    3-Hydroxybenzaldehyde (Standard) is the analytical standard of 3-Hydroxybenzaldehyde. This product is intended for research and analytical applications. 3-Hydroxybenzaldehyde (3-HBA) is a precursor compound for phenolic compounds like Protocatechuic aldehyde (PCA) (HY-N0295). 3-Hydroxybenzaldehyde, produced by 3-hydroxybenzyl-alcohol dehydrogenase, is a substrate of aldehyde dehydrogenase (ALDH) in rats and humans. 3-Hydroxybenzaldehyde has vasculoprotective effects in vitro and in vivo. 3-Hydroxybenzaldehyde is proming for research of atherosclerosis[1][2][3][4].
    3-Hydroxybenzaldehyde (Standard)
  • HY-177639
    Lefelsiran
    		Inhibitor
    Lefelsiran (NN-6020) is a siRNA targeted to ALDH2. It is used for the study of alcohol use disorder.
    Lefelsiran
  • HY-182636
    MT16-001
    MT16-001 is a cell-permeable UCHL1 inhibitor with an IC50 value of 580 nM. MT16-001 also exhibits considerable inhibitory activity against USP30, and shows selectivity for other UCH family deubiquitinases (DUBs) as well as the broader proteome. MT16-001 binds covalently to the cysteine residue at the active site of UCHL1, and forms covalent interactions with ALDH2, ALDH9A1 and GATD3A in intact cells. Meanwhile, as a cytotoxic agent, it displays a steep dose-response curve in human embryonic kidney cells. MT16-001 can be used for research on various cancers, liver fibrosis and pulmonary fibrosis.
    MT16-001
  • HY-W001083S1
    3-Hydroxyphenylacetic acid-d5
    		Inducer
    2-(3-Hydroxyphenyl-2,4,6-d3)acetic-2,2-d2 acid is the deuterium labeled 3-Hydroxyphenylacetic acid (HY-W001083). 3-Hydroxyphenylacetic acid is an orally active flavonoid metabolite produced by intestinal flora, with blood pressure-lowering activity. 3-Hydroxyphenylacetic acid can also inhibit ferroptosis by upregulating the expression of GPX4, thereby improving spermatogenic dysfunction in aged mice. In addition, abnormal levels of 3-Hydroxyphenylacetic acid are closely related to certain diseases, such as autism spectrum disorders.
    3-Hydroxyphenylacetic acid-d<sub>5</sub>
  • HY-D3183
    AldRed 659-A
    		Substrate
    AldRed 659-A is a red-shifted fluorescent substrate for aldehyde dehydrogenase (ALDH). AldRed 659-A exhibits only minimal fluorescent uptake shift in comparison with DEAB (ALDH inhibitor)-treated control.
    AldRed 659-A
  • HY-W001083R
    3-Hydroxyphenylacetic acid (Standard)
    		Inducer
    3-Hydroxyphenylacetic acid (Standard) is the analytical standard of 3-Hydroxyphenylacetic acid (HY-W001083). This product is intended for research and analytical applications. 3-Hydroxyphenylacetic acid is an orally active flavonoid metabolite produced by intestinal flora, with blood pressure-lowering activity. 3-Hydroxyphenylacetic acid can also inhibit ferroptosis by upregulating the expression of GPX4, thereby improving spermatogenic dysfunction in aged mice. In addition, abnormal levels of 3-Hydroxyphenylacetic acid are closely related to certain diseases, such as autism spectrum disorders.
    3-Hydroxyphenylacetic acid (Standard)
  • HY-121817R
    Sulfiram (Standard)
    		Inhibitor
    Sulfiram (Standard) is the analytical standard of Sulfiram (HY-121817). This product is intended for research and analytical applications. Sulfiram, an ectoparasiticide, is a weak aldehyde dehydrogenase (ALDH) inhibitor. Sulfiram can be used for the study of scabies.
    Sulfiram (Standard)
  • HY-RS00569
    Aldh2 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Aldh2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Aldh2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Aldh2 Mouse Pre-designed siRNA Set A
  • HY-142708
    α-Pyridoin
    		Inhibitor
    α-Pyridoin is a unique enediol antioxidant.
    α-Pyridoin
  • HY-N11451
    Lacto-N-fucopentaose III
    		Activator
    Lacto-N-fucopentaose III (LNFP-III) is an immune modulator. Lacto-N-fucopentaose III reduces the severity of experimental autoimmune encephalomyelitis (EAE) and CNS inflammation.
    Lacto-N-fucopentaose III
  • HY-158268
    4-Hydroxynonenal/BSA
    		Inhibitor
    4-Hydroxynonenal/BSA is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    4-Hydroxynonenal/BSA
  • HY-146240
    ALDH1A1-IN-3
    		Inhibitor
    ALDH1A1-IN-3 (compound 57) is an excellent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor with an IC50 value of 0.379 μM. ALDH1A1-IN-3 can effectively improve glucose consumption in HepG2 cells. ALDH1A1-IN-3 can be used for researching glucose metabolism improvement.
    ALDH1A1-IN-3
  • HY-134917
    Aldi-2
    		Inhibitor
    Aldi-2 is a potent and specific covalent inhibitor of aldehyde dehydrogenases (ALDHs) with IC50s of 2.5, 6.4 and 1.9 μM against ALDH1A1, ALDH2 and ALDH3A1, respectively. Aldi-2 can be utilized in cancer research.
    Aldi-2
  • HY-113734
    CM026
    		Inhibitor 98.36%
    CM026 is a selective aldehyde dehydrogenase 1A1 inhibitor with submicromolar inhibitory activity against aldehyde dehydrogenase 1A1. Its inhibitory mechanism is related to binding to the aldehyde binding pocket and utilizing a unique glycine residue. It can be used as a chemical tool to study the role of this enzyme in disease.
    CM026
Cat. No. Product Name / Synonyms Application Reactivity
Aldehyde Dehydrogenase (ALDH) Isoform Comparison

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